This is a manip of two of the original characters I'm working with. On the right is Eve, who may be passing familiar to some folks (I've done a few other pics of her), on the left is her girlfriend, Chloe.
Not gonna go into too much detail about how I did what... the base pic was a 3D render in DAZ Studio (a freeware wannabe Poser clone, for the uninitiated), I stuck on the faces of Audrey Tautou (Eve) and Alexis Bledel (Chloe), made all their clothing from scratch, and did the background in 3D using Bryce 4 with some lighting and texture touchups in Photoshop 7. If anyone wants any more details, email or PM me, or take a look at the ridicolously detailed art notes for this image over at comics2film.